Millions of people use cannabis alongside prescription medications. Some combinations are safe. Others require monitoring. A few are genuinely dangerous. This evidence-based database covers 28+ medications with plain-English explanations of what happens, why it happens, and what to do about it.
Try: "warfarin", "Xanax", "opioids", "blood pressure", "Prozac"
28+
Medications Covered
19
Drug Categories
5
Severity Levels
30+
Peer-Reviewed Sources
Medical Disclaimer: This tool is for educational purposes only and does not constitute medical advice. Always consult your prescribing physician, pharmacist, or healthcare provider before changing how you use cannabis alongside any medication. Do not stop or change prescription medications based on this information alone.
Type your medication name or brand name in the search box above — or browse by category in the sidebar.
Review the severity rating, mechanism of interaction, and cannabinoid-specific effects for your medication.
Follow the recommendation and always inform your prescribing physician or pharmacist about your cannabis use.
These interactions require the most attention. If you take any of these medications, read the full profile.
Most drug interactions involving cannabis happen because of the CYP450 enzyme system — a family of liver enzymes responsible for metabolizing (breaking down) most medications. CBD is a particularly potent inhibitor of several key CYP450 enzymes, especially CYP2C9, CYP3A4, CYP2D6, and CYP2C19.
When CBD inhibits these enzymes, medications that depend on them for metabolism accumulate in the bloodstream — their levels rise higher than intended. This can intensify both the therapeutic effects and the side effects of those medications. In some cases (like warfarin), even a modest level increase can be dangerous.
THC interacts differently — its primary interactions are pharmacodynamic (affecting the same body systems as the medication) rather than pharmacokinetic (affecting drug levels). THC's cardiovascular effects (tachycardia, blood pressure changes) are the most clinically relevant for drug interactions.